ABSTRACT
To determine efficacy of lodoxamide as compared to that of sodium cromoglycate when used for the treatment of vernal keratoconjunctivitis. Prospective comparative clinical trial. This study was carried out at the Department of Pharmacology and Therapeutics Basic Medical Sciences Institute [BMSI] in collaboration with Department of Ophthalmology Jinnah Postgraduate Medical Center [JPMC] Karachi from April 2010 to October 2010. A total of untreated 80 cases with clinical diagnosis of vernal keratoconjunctivitis [VKC] of 5-29 years of age and of both sexes were included in this study. Patients of other types of allergic conjunctivitis and of VKC already on medication were not included in this study. Follow up visits were carried out at fortnightly intervals for the period of at least three [03] months to rule out comparative efficacy of the two drugs. We studied a total of 80 cases, 56 males [70%] and 24 females [30%] with diagnosis of VKC. All cases were divided in two groups; group A and group B. Group A comprised of 40 patients who used lodoxamide whereas; Group B comprised 40 patients who used sodium cromoglycate. No significant difference in demographic features was found in two groups [p>0.05]. The results showed significant improvement in all symptoms and signs in 60 days of study in group A [lodoxamide] and in group B [sodium cromoglycate] improvement was observed in 90 days of the study [p<0.05]. Improvement in all the symptoms and signs was earlier [within 30 days of study] in group A than in group B
ABSTRACT
To evaluate the outcome of low dose intralesional steroid injections used in superficial infantile capillary hemangioma [SICH] of eye lid. Prospective Study. This study was conducted at Department of Ophthalmology, Chandka Medical College Hospital Larkana from September 2001 to October 2011. Only, patients with congenital SICH involving eye lids with closure of visual axis were included in this study and SICH involving eye lids without closure of visual axis were excluded from study. The diagnosis of disease was based on history and clinical examination. All the patients were treated by mixture of low dose intralesional steroids triamcinolone 20mg [0.5ml] and dexamethasone 4mg [1.0ml]. A total of three injections were given with interval of two months. After injection, the follow-up examinations were carried out at first week, every second month for six months and then annually. After treatment, outcome was recorded. The successful outcome was labeled when there was complete regression of lesion. Out of 37 patients 28[75.67%] were female and 9[24.32%] were male with female to male ratio of 3.1:1 and age range of 2 to 12 months. All the patients had unilateral growth; with left eye lid involvement in 22[59.45%] cases and right eye lid involvement in 15[40.54%] cases. The successful outcome seen was early regression of lesion in 24[64.86%] cases by age of 2.3 years and in 13[35.13%] cases by age of 3.1 years. The outcome of this study was that, early treatment of SICH of eye lid with intralesional steroid injections resulted reliable, quick, beneficial effects and good cosmetically functional eye lid by early involution of growth
Subject(s)
Humans , Male , Female , Neoplastic Syndromes, Hereditary , Eyelid Neoplasms , Eyelids , Steroids , Injections, Intralesional , Treatment Outcome , Prospective StudiesABSTRACT
It is an open-label comparative study, conducted at the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. The study comprised of two drugs of different groups; total eighty adult patients were enrolled [44 female and 36 male] from the department of psychiatry. Enrolled patients received trazodone 50 mg daily which was gradually increased to 150 mg in divided doses and paroxetine 20 mg daily for a period of 90 days. The results revealed that paroxetine is more effective and has less adverse effects than the trazodone. There was significant improvement in symptoms of sexual disturbance and weight loss of major depressive disorder patients receiving paroxetine